Cholesterol synthesis inhibitors protect against platelet-activating factor-induced neuronal damage

Table 2 Squalene reverses the protective effects of squalestatin

Treatment	Substrate
	None	50 μM Squalene	100 μM Mevalonate
	*Neuronal survival (% of control)*
None	31 ± 6	32 ± 4	30 ± 5
100 nM Squalestatin	95 ± 7	40 ± 9	93 ± 5
500 nM Simvastatin	94 ± 4	42 ± 9	34 ± 8

The survival of primary cortical neurons treated for 24 hours with combinations of either squalestatin or simvastatin together with either squalene or mevalonate as shown, and subsequently incubated with 100 nM PAF. Values shown are the mean average neuronal survival ± SD from 12 observations.

ISSN: 1742-2094