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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Repeated administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes

Figure 1

Noradrenaline levels in hippocampus and cortex. For all graphs WT/VEH (white), WT/DSP-4 (grey), TG/VEH (stripes), TG/DSP-4 (black). NA levels in hippocampus (A) and cortex (B) in WT and TG mice (8 months). Hippocampal NA levels are significantly lower in WT/VEH (p < 0.05) and TG/DSP-4 (p < 0.05) mice relative to WT/DSP-4 mice. In cortex TG/VEH mice show a trend towards lower NA levels compared with WT/VEH (p = 0.08) and WT/DSP-4 (p = 0.09). TG/DSP-4 NA levels are no different to WT/VEH or WT/DSP-4. (Mean ± S.E.M. ng/ml; WT/VEH 293 ± 49; TG/VEH 194 ± 14; WT/DSP-4 289 ± 30; TG/DSP-4 262 ± 41). At 11 months, NA levels are significantly reduced in both hippocampus (p < 0.05) (C) and cortex (p < 0.05) (D) in TG mice (hippocampus: mean ± S.E.M. ng/ml, WT/VEH 172 ± 16; TG/VEH 113 ± 15; cortex: WT/VEH 224 ± 28; TG/VEH 147 ± 12). TG/DSP-4 mice have lower levels of cortical (p < 0.0001) and hippocampal (p < 0.0001) NA compared with WT/DSP-4 (cortex: mean ± S.E.M. ng/ml, WT/DSP-4 229 ± 19; TG/DSP-4 63 ± 5; hippocampus: WT/DSP-4 182 ± 23; TG/DSP-4 62 ± 14). TG/DSP-4 mice have lower levels of cortical (p < 0.01) and hippocampal (p < 0.05) NA compared with TG/VEH.

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Journal of Neuroinflammation

ISSN: 1742-2094