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Figure 10 | Journal of Neuroinflammation

Figure 10

From: Repeated administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes

Figure 10

mRNA levels in cortex, 11 months. mRNA levels in WT and TG mice (11 months). mRNA levels are raised in TG/DSP-4 vs. TG/VEH for IL-1β (A). Levels of IκBα are reduced in TG mice and DSP-4 treatment reduces IκBα in both WT and TG mice (B). TG mice have elevated MIP1-α (C) and MIP1-β (D) TNF-α (E), GFAP (F), FasL (H), CCR5 (I), RANTES (J) are raised in TG mice and DSP-4 does not modify this. ***p < 0.001, **0.01, *0.05 vs. WT/VEH and DSP-4 treatment does not modify this.

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Journal of Neuroinflammation

ISSN: 1742-2094