mRNA levels in cortex, 11 months. mRNA levels in WT and TG mice (11 months). mRNA levels are raised in TG/DSP-4 vs. TG/VEH for IL-1β (A). Levels of IκBα are reduced in TG mice and DSP-4 treatment reduces IκBα in both WT and TG mice (B). TG mice have elevated MIP1-α (C) and MIP1-β (D) TNF-α (E), GFAP (F), FasL (H), CCR5 (I), RANTES (J) are raised in TG mice and DSP-4 does not modify this. ***p < 0.001, **0.01, *0.05 vs. WT/VEH and DSP-4 treatment does not modify this.