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Figure 2 | Journal of Neuroinflammation

Figure 2

From: The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection

Figure 2

CDDO-Me downregulates expression of mRNAs for pro-inflammatory genes. (A) BV2 microglia were pre-treated with 10 nM CDDO-Me for 17 hr before a 4-hr stimulation as indicated. (B) Microglia from post-natal day 2 (P2) wild-type mice were pre-treated with 100 nM CDDO-Me for 24 hr before a 4 hr stimulation as indicated. (C) Peripheral macrophages from adult wild-type mice were pre-treated with 100 nM CDDO-Me for 24 hr before a 4-hr stimulation as indicated. Values represent mean ± S.E.M. and are expressed relative to vehicle-treated, vehicle-stimulated conditions. Values were analyzed by two-way ANOVA followed by Bonferroni's post hoc. * denotes significance at p < 0.05, *** denotes significance at p < 0.001.

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Journal of Neuroinflammation

ISSN: 1742-2094