LPS-associated anhedonia is blocked by minocycline. Mice were injected i.p. with vehicle or minocycline for three consecutive days. On the third day mice were challenged with saline or LPS i.p. and sucrose preference was determined 24 to 39 h post LPS. Bars represent the mean ± SEM (n = 15). Means with different letters (a or b) are significantly different (P < 0.05) from each other.