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Figure 5 | Journal of Neuroinflammation

Figure 5

From: Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2

Figure 5

Effects of COX-2 deficiency on LPS-induced expression of ROS-generating enzymes. Quantitative real time-PCR analysis of iNOS (A), gp91phox(B) and p67phoxmRNA (C) for COX-2+/+ and COX-2-/- mice that received icv injection of LPS or vehicle 24 h before sacrifice. (D) Quantification of p67phox protein levels, relative to GAPDH internal loading control in the whole brain. (E) Representative immunoblot of p67phox expression in COX-2+/+ and COX-2-/- mice 24 h after icv injection of LPS or vehicle. Data are presented as mean ± SEM (n = 4-6). ***P < 0.001 compared to the corresponding vehicle-injected mice; #P < 0.05, ##P < 0.01 compared to the LPS-injected COX-2+/+ mice.

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