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Figure 1 | Journal of Neuroinflammation

Figure 1

From: VEGF receptor antagonist Cyclo-VEGI reduces inflammatory reactivity and vascular leakiness and is neuroprotective against acute excitotoxic striatal insult

Figure 1

Time-dependent gliosis and effects of Cyclo-VEGI on microgliosis, astrogliosis and VEGF expression at 1 d post QUIN-intrastriatal injection. (A) Representative staining for microglia (ED1 marker) and astrocytes (GFAP marker) at 6 hr, 1 d and 7 d QUIN-injection; typical marker immunoreactivities (ir) for control PBS (7 d injection) are also shown. Scale bar represents 150 μm. (B) Photomicrographs of immunofluorescence staining for different injection protocols (1 d intra-striatal injection). Typical patterns of staining are shown for ED1 ir microglia (upper panels), GFAP ir astrocytes (middle panels), and VEGF expression (lower panels). Scale bar represents 60 μm for ED1 panel and 300 μm for VEGF panel. The insets in VEGF panels show cell-associated VEGF; scale bar = 25 μm. (C) Bar graphs for ED1 (upper), GFAP (middle) and VEGF (lower) ir. Data are mean ± SEM (n = 5 animals/group). *p < 0.05 compared with PBS-injected group. #p < 0.05 compared with QUIN-injected group.

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Journal of Neuroinflammation

ISSN: 1742-2094