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Figure 3 | Journal of Neuroinflammation

Figure 3

From: VEGF receptor antagonist Cyclo-VEGI reduces inflammatory reactivity and vascular leakiness and is neuroprotective against acute excitotoxic striatal insult

Figure 3

Effects of Cyclo-VEGI on intactness of BBB. (A) Photomicrographs of representative fluorescence images of Evans blue dye (upper panels) and fibrinogen (lower panels) with the different striatal injections (1 d post-injection): PBS (left panel), QUIN-injection (left middle panel), QUIN-injected rats with Cyclo-VEGI (right middle panel) and Cyclo-VEGI alone (right panel) treatment. Scale bar represents 500 μm. The insets in fibrinogen panels show typical RECA-1 ir; scale bars represent 150 μm for fibrinogen panel and 100 μm for RECA-1 panel. (B) Quantitative analysis of Evans blue dye (upper graph) and fibrinogen (lower graph) fluorescence intensity for the different procedures. Data are mean ± SEM (n = 5 animals/group). *P < 0.05 vs. PBS-injected group. #P < 0.05 vs. QUIN-injected group.

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Journal of Neuroinflammation

ISSN: 1742-2094