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Figure 5 | Journal of Neuroinflammation

Figure 5

From: Novel role for SLPI in MOG-induced EAE revealed by spinal cord expression analysis

Figure 5

Downregulation of the cholesterol biosynthesis pathway during EAE. A: Summary of the average expression values of genes of the cholesterol biosynthesis pathway (± std dev). As we only noticed minor differences of the expression of these genes within the observed disease phases, the expression values obtained for the acute, recovery and relapsing disease phase were merged to one value representing the average expression of the particular gene during EAE. All values are correlated to the expression values of the corresponding gene in the spinal cord of healthy rats. The EAE gene expression was compared to the expression within healthy rats using a paired t test. *: p < 0.05. B: Average cholesterol concentration in spinal cord extracts. Rats from distinct disease phase were sacrificed, their spinal cord dissected and lipids and lipoproteins extracted by RIPA buffer. Cholesterol concentrations were determined as described in Material and Methods.

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