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Figure 8 | Journal of Neuroinflammation

Figure 8

From: Novel role for SLPI in MOG-induced EAE revealed by spinal cord expression analysis

Figure 8

SLPI promotes proliferation of adult neural stem cells and induces cyclin D1. A: Proliferation of rat neural stem cells after treatment with SLPI or VEGF, respectively. Cells were treated with indicated amounts of SLPI or VEGF for three days. Afterwards, they were pulsed with 10 μM BrdU. Proportion of BrdU-positive cells (+ std dev) was determined with the FITC BrdU Flow Kit. Presentation of a representative result of three experiments. *:p < 0.05 (according to a One Way ANOVA analysis of variance (Holm-Sidak method). B: RealTime-PCR assessment of cyclin D1 expression (n = 3, + std dev) in rat adult stem cells after an incubation period of three days with the indicated amounts of SLPI or VEGF, respectively. C: Determination of cyclin D1 expression (n = 3, + std dev) of adult neural stem cells treated for three days with indicated amounts of SLPI or α1-AT. Presentation of a representative result of three experiments.*:p < 0.05 (according to a One Way ANOVA analysis of variance (Holm-Sidak method)).

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