Microglia (but not astroglia) mediate the neuroprotection of FLZ. Different kinds of cultures were pretreated with 10 μM FLZ for 1 h, and then 0.25 μM MPP+ was added. DA neurotoxicity was measured by [3H]-DA uptake assay 7 days later. The data are expressed as percentages of control culture values, and represent the mean ± S.E.M. for three independent experiments, each performed with triplicate samples. ### p < 0.001 compared with vehicle-treated control cultures; *** p < 0.001 compared to MPP+ treatment group.