Figure 7

Quantification of GFAP⁺ astrocytes in hippocampus and cortex of the TgAPPsw mice with reduced GRK5. Both the numbers of GFAP⁺ astrocytes (A &B) and the intensity of GFAP-IR (C &D) in hippocampus (A &C) and cortex (B &D) of WT, heterozygote GRK5KO, TgAPPsw, and the double mice were quantified as described in methods. Two way-ANOVAs revealed significant interactions between APPsw and GRK5 gene modifications with the interaction factors of p < 0.05 for panel A, and p < 0.01 for panels B, C, and D. The results for Bonferroni post-hoc comparisons of the means were shown as indicated. **P < 0.001 vs WT or GRK5KO; #P < 0.01, ##P < 0.001 vs TgAPPsw mice.