Minozac suppresses proinflammatory cytokine upregulation in cortex following TBI. Mice were subjected to TBI or sham procedure. At 3 hr and 9 hr following TBI, mice were injected with Mzc (5 mg/kg/dose) or saline diluent (VEH). Mice were sacrificed at 12 hr post-injury, and levels of the proinflammatory cytokines IL-1β (A), IL6 (B), TNFα (C) and the chemokine CCL2 (D) in cortical extracts were measured by ELISA. Mzc treatment resulted in significant attenuation of the increase in cytokines measured in the TBI group treated with saline vehicle. Cytokine levels in the Mzc-treated TBI mice were not significantly different from the sham controls. Data are expressed as mean ± S.E.M of n = 5–7 animals per group. #P < 0.001 vs Sham control; **P < 0.01 vs TBI-VEH by ANOVA.