Minozac attenuates hippocampal-dependent Y-maze behavioral impairment following TBI. Mice were subjected to TBI or sham procedure. At 3 hr and 9 hr following TBI, mice were injected with Mzc (5 mg/kg/dose) or saline diluent (VEH) via intraperitoneal injection. On days 7 through 28 of recovery, hippocampal function was assessed by alternation in the Y-maze. Treatment with Mzc prevented neurobehavioral impairment resulting from TBI. Data are expressed as mean ± S.E.M of n = 5–7 animals per group. *P < 0.05 vs TBI-VEH by ANOVA.