Minozac treated animals have attenuated increase in brain water content following TBI. Mice were subjected to TBI or sham procedure. At 3 hr and 9 hr following TBI, mice were injected with Mzc (5 mg/kg/dose) or saline diluent (VEH) via intraperitoneal injection. Mice were sacrificed 24 hr post-injury, and brain water content was measured in coronal sections by wet dry methods. Water content increased significantly following TBI in mice treated with saline but not when treated with Mzc. Data are expressed as mean ± S.E.M of n = 9–13 animals per group. *P < 0.05 vs sham control by ANOVA.