Association of alleles carried at TNFA -850 and BAT1-22 with Alzheimer's disease

Table 1 Analysis of Genotype and Allele frequencies of the BAT1 -22, TNFA -308 and TNFA -850 polymorphisms

Marker	Genotype or allele	Ctrl numbers (%)	AD numbers (%)
BAT1 -22	1/1	144 (40.1)	117 (43.0)
	1/2	167 (46.5)	138 (50.7)
	2/2	48 (13.4)	17 (6.3)^a
	1	455 (63.4)	372 (68.4)
	2	263 (36.6)	172 (31.6)
TNFA -308	1/1	226 (63.0)	188 (69.1)
	1/2	104 (29.0)	70 (25.7)
	2/2	29 (8.0)	14 (5.1)
	1	556 (77.4)	446 (82.0)
	2	162 (22.6)	98 (18.0)^b
TNFA -850	1/1	287 (79.9)	183 (67.3)
	1/2	61 (17.0)	70 (25.7)
	2/2	11 (3.1)	19 (7.0)^c
	1	635 (88.4)	436 (80.1)
	2	83 (11.6)	108 (19.9)^d

Ctrl = Control cases without AD pathology
AD = Alzheimer's disease cases
^a BAT1 -22*2/2 versus non-2/2 in AD, P < .005 (Pearson χ² = 8.49) OR = 0.43 (95% CI = 0.24 – 0.77).
^b TNFA -308*2 allele in AD, P = .048 (Pearson χ² = 3.91) OR = 0.75 (95% CI = 0.57 – 1.00).
^c TNFA -850*(2/2, 1/2) versus 1/1 in AD, P < .001 (Pearson χ² = 13.06) OR = 1.94 (95% CI = 1.35 – 2.78.0).
^d TNFA -850*2 allele in AD, P < .001 (Pearson χ² = 16.57) OR = 1.90 (95% CI = 1.39 – 2.59).

ISSN: 1742-2094