Figure 2

Reduction of cerebral glucose uptake in septic encephalopathy. Shown are five representative transversal [¹⁸F]FDG-PET brain slices of rats treated with vehicle (Con, first row) or bacterial lipopolysaccharide (LPS, second row) at 24 h. Corresponding region-of-interest (ROI) masks are displayed below. B, Quantification of [¹⁸F]FDG uptake (relative to cerebellar (CB) ROI) in vehicle-treated wild-type (Con) and LPS-treated mice (LPS) at 24 h. Significant differences were detected in frontal cortex (FC), parietal cortex (PC) and temporal cortex (TC). In contrast, evaluation of the caudate nucleus (NC), thalamus (THL) and hippocampus (HC) did not yield significant results (mean ± SEM; n = 5 animals/group; Student's t test; *p ≤ 0.05, **p ≤ 0.01).