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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt

Figure 1

Pioglitazone inhibits LPS-induced NO production in microglia-enriched cultures. Microglia cultures were treated with pioglitazone (1 μM and 10 μM) 1 hr before LPS treatment, and 48 hrs later NO levels were measured. LPS significantly induced NO generation, and pretreatment with pioglitazone inhibited this LPS-induced NO production in a dose-dependent manner. Data presented are representative of three independent experiments (n = 3). (***p < 0.001 vs. control ###p < 0.001 vs. LPS)

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Journal of Neuroinflammation

ISSN: 1742-2094