Figure 3From: Mannan-Abeta28conjugate prevents Abeta-plaque deposition, but increases microhemorrhages in the brains of vaccinated Tg2576 (APPsw) miceEffects of vaccination with mannan-Aβ 28 on microglial and astrocyte activation in Tg2576 mice. Image analysis of cortical sections performed after staining with anti-CD45 (A) and anti-GFAP (B) antibodies of brain sections from non-immunized controls and mice immunized with mannan-Aβ28. Significantly less microglial activation (P = 0.0003) and lower level of astrocytosis (P = 0.3263) were detected after immunization with mannan-Aβ28 compared to non-immunized control mice. Representative pictures of staining with anti-CD45 (C) and anti-GFAP (D) antibodies showing a decrease in immunoreactivity in hippocampal areas of brain sections of mice immunized with mannan-Aβ28 versus control non-immunized mice. Original magnifications: 5×, scale bar = 200 μm.Back to article page