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Figure 4 | Journal of Neuroinflammation

Figure 4

From: Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway

Figure 4

MyD88-dependent induction of neurotoxicity and glutaminase expression in microglia. (A) Neurotoxicity of MCM from wild type (WT) and MyD88-deficient microglia cultures either non-stimulated (MCM) or treated with necrotic HT22 neurons (MCM (Nec.)). (B) RT-PCR analysis of glutaminase expression of wild type or MyD88-deficient microglia treated or not treated with necrotic HT22 neurons. (C) Analysis of L-Glutamic acid levels in MCM of microglial cell cultures. Results are shown as mean ± SD and are representative of at least two experiments. *** p < 0.001 and * p < 0.05.

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Journal of Neuroinflammation

ISSN: 1742-2094