Figure 1

TMEV injections, timing of experimental groups, and scoring of CD45+ activation. A) Schematic showing injection site in cerebellum, both sagittal and coronal views shown. Adapted from the atlas of Paxinos and Franklin [33]. B) Time line of experimental regimen. C) Examples of representative CD45+ cell activation showing scores of 0 through 3 in the hippocampus. Scale bar = 100 μm. D) Cells in spinal cord grey matter showing range of morphology of CD45+ cells from non-activated (0) to highly activated (3) with intermediate morphology in between. Scale bar = 10 μm.