Figure 13

Measurement of cortical perfusion during focal cerebral ischemia in TNFα-transgenic and non-transgenic rats. The multi-line plot shows laser-Doppler flowmetry (LDF) measurements of cortical perfusion expressed as a percentage of pre-ischemic baseline in TNFα-transgenic (TNFα-Tg; n = 19) rats and non-Tg littermates (n = 21). Measurements were made every 5 minutes during 10 minutes of pre-ischemic baseline, 60 minutes of ischemia, and 30 minutes of post-ischemic reperfusion. Values were calculated as a percentage of pre-ischemic baseline and are presented as means ± SD. The TNFα-Tg rats had significantly lower mean LDF at 5 and 10 minutes immediately after the onset of ischemia (P = 0.0016 and 0.034, respectively; repeated measures ANOVA). *p ≤ 0.05; **p ≤ 0.01