Skip to main content

Advertisement

Table 1 Neurologic and behavioral findings in SPF SW female mice infected at 7 months of age and tested at 12 months of age

From: Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection

APPEARANCE LOCOMOTION ANS OPEN FIELD ACTIVITY
Condition Grooming Body Position Piloerection Tail Damage Tremor Palpebral Closure Lacrimation Weight (gm) Spatial Locomotion Gait Urination/Defecation Sniffs Rears Center Freezing Latency to move (sec)
Control Good - - - - - - 39.4 Active - - 2 20 4 0 4
Control Good - - - - - - 52.3 Active - - 4 4 2 0 22
Control Good - - - - - - 45.0 Active - - 6 13 3 0 41
Control Good - - - - - - 50.5 Active - - 1 0 7 0 120
Control Good - - - - - - 50.6 Active - - 4 9 7 0 10
Control Good - - - - - - 58.5 Active - - 1 2 9 0 1
Infected Poor + + + + - - 43.8 Slow + + nd nd nd nd nd
Infected Good + + + - - - 41.2 Active + + 0 0 0 0 180
Infected Very Poor + - + + - - 42.0 None + + 0 0 0 0 180
Infected Very Poor + + - + + + 35.3 None + + nd nd nd nd nd
Infected Good - + + - - - 34.9 Active - + 0 0 0 0 180
Infected Very Poor + + - + + + 34.8 Slow + + 0 0 0 0 180
Infected Poor + + + + + + 35.6 Slow + + 1 3 1 1 24
Infected Sub-normal + + - + + + 36.2 Active - + 0 2 10 1 6
Infected Very Poor + + + - - + 58.0 None - + 0 0 0 0 180
Infected Poor + + + + - - 54.2 Slow - + 2 0 1 2 56
P-values 0.018 0.001 0.001 0.011 0.011 0.23 0.093 0.059 0.035 0.034 < 0.001 0.0055 0.016 0.017 0.11 0.021
  1. + = abnormal, - = normal, nd = not done. Figure 1 shows representative examples of abnormal grooming, body position, piloerection, and tail damage (Figure 1 B, C) in infected mice when compared with control shown in Figure 1A.