Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection

Table 3 Histopathology in brain regions of uninfected and infected mice

Mouse	Meningitis	PV Cuffing				Inflammatory Lesions				Calcifications				Cysts				Inflammation With Cysts
		Co	D	H	Ce	Co	D	H	Ce	Co	D	H	Ce	Co	D	H	Ce	Co	D	H	Ce
U1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
U2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
U3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
U4	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
U5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
U6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
I1	2	1	2	2	0	2	4	0	0	4	0	0	4	4	7	1	0	1	0	0	0
I2	1	1	1	2	2	2	0	1	0	0	0	0	4	2	0	0	0	0	0	0	0
I3	1	1	2	1	1	0	1	1	1	0	0	0	1	2	3	2	0	0	0	1	0
I4	2	1	3	2	2	0	1	1	1	0	0	0	0	3	5	1	0	0	1	1	0
I5	3	1	2	1	0	2	2	0	1	0	1	0	3	4	1	2	0	0	0	0	0
I6	3	1	1	3	1	1	1	4	0	0	2	0	3	2	2	2	1	0	0	1	0
I7	3	1	2	2	2	4	3	2	0	0	0	0	2	3	2	2	1	0	0	0	0
I8	1	1	1	2	2	1	0	1	0	0	0	0	1	0	1	1	0	0	0	0	0

Abbreviations: U = uninfected, I = infected, U or I is followed by mouse number; Co = Cortex; D = Diencephalon; H = Hippocampus; Ce = Cerebellum
Scoring System: Meningitis scored 1 = mild; 2 = moderate; 3 = severe; PV cuffing 1 = mild; 2 = moderate; 3 = severe; Inflammatory Lesions scored according to number of lesions identified in one section; Calcifications Scored according to number of calcifications identified in one section; Cysts scored according to number of cysts identified in one section; Inflammation with cysts scored according to number of cysts adjacent to inflammatory lesion, by implication other cysts were 'sitting' in apparently normal brain.

ISSN: 1742-2094

Mouse	Meningitis	PV Cuffing				Inflammatory Lesions				Calcifications				Cysts				Inflammation With Cysts
		Co	D	H	Ce	Co	D	H	Ce	Co	D	H	Ce	Co	D	H	Ce	Co	D	H	Ce
U1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
U2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
U3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
U4	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
U5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
U6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
I1	2	1	2	2	0	2	4	0	0	4	0	0	4	4	7	1	0	1	0	0	0
I2	1	1	1	2	2	2	0	1	0	0	0	0	4	2	0	0	0	0	0	0	0
I3	1	1	2	1	1	0	1	1	1	0	0	0	1	2	3	2	0	0	0	1	0
I4	2	1	3	2	2	0	1	1	1	0	0	0	0	3	5	1	0	0	1	1	0
I5	3	1	2	1	0	2	2	0	1	0	1	0	3	4	1	2	0	0	0	0	0
I6	3	1	1	3	1	1	1	4	0	0	2	0	3	2	2	2	1	0	0	1	0
I7	3	1	2	2	2	4	3	2	0	0	0	0	2	3	2	2	1	0	0	0	0
I8	1	1	1	2	2	1	0	1	0	0	0	0	1	0	1	1	0	0	0	0	0

Mouse	Meningitis	PV Cuffing				Inflammatory Lesions				Calcifications				Cysts				Inflammation With Cysts
		Co	D	H	Ce	Co	D	H	Ce	Co	D	H	Ce	Co	D	H	Ce	Co	D	H	Ce
U1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
U2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
U3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
U4	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
U5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
U6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
I1	2	1	2	2	0	2	4	0	0	4	0	0	4	4	7	1	0	1	0	0	0
I2	1	1	1	2	2	2	0	1	0	0	0	0	4	2	0	0	0	0	0	0	0
I3	1	1	2	1	1	0	1	1	1	0	0	0	1	2	3	2	0	0	0	1	0
I4	2	1	3	2	2	0	1	1	1	0	0	0	0	3	5	1	0	0	1	1	0
I5	3	1	2	1	0	2	2	0	1	0	1	0	3	4	1	2	0	0	0	0	0
I6	3	1	1	3	1	1	1	4	0	0	2	0	3	2	2	2	1	0	0	1	0
I7	3	1	2	2	2	4	3	2	0	0	0	0	2	3	2	2	1	0	0	0	0
I8	1	1	1	2	2	1	0	1	0	0	0	0	1	0	1	1	0	0	0	0	0

Mouse	Meningitis	PV Cuffing				Inflammatory Lesions				Calcifications				Cysts				Inflammation With Cysts
		Co	D	H	Ce	Co	D	H	Ce	Co	D	H	Ce	Co	D	H	Ce	Co	D	H	Ce
U1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
U2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
U3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
U4	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
U5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
U6	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
I1	2	1	2	2	0	2	4	0	0	4	0	0	4	4	7	1	0	1	0	0	0
I2	1	1	1	2	2	2	0	1	0	0	0	0	4	2	0	0	0	0	0	0	0
I3	1	1	2	1	1	0	1	1	1	0	0	0	1	2	3	2	0	0	0	1	0
I4	2	1	3	2	2	0	1	1	1	0	0	0	0	3	5	1	0	0	1	1	0
I5	3	1	2	1	0	2	2	0	1	0	1	0	3	4	1	2	0	0	0	0	0
I6	3	1	1	3	1	1	1	4	0	0	2	0	3	2	2	2	1	0	0	1	0
I7	3	1	2	2	2	4	3	2	0	0	0	0	2	3	2	2	1	0	0	0	0
I8	1	1	1	2	2	1	0	1	0	0	0	0	1	0	1	1	0	0	0	0	0