C5a mediated protection against glutamate mediated GluR2 depletion in vitro is specific for both C5a and glutamate receptors. The hrC5a mediated protection of GluR2 in the presence of 50 μM glutamate for 24 hrs in primary neuronal cultures from WT mice was absent when co-treated with C177. All results are expressed as mean ± SD. WT Control vs Glutamate: **p < 0.0001; WT Control vs Glutamate+C5a: *p < 0.01; WT Glutamate vs Glutamate+C5a: *p < 0.05; Control vs Glutamate+C177+C5a: *p < 0.03. The western blot shows the GluR2 expression in the same experiment.