Group | AR+AC | Asthma | AD | FA | CRS & ROM | PID2 |
|---|
| Â | Â | Atopy+ | Atopy - | Â | IgE | non-IgE | Â | Â |
|---|
ASD1 | Â | Â | Â | Â | Â | Â | Â | Â |
Test3 | 7/26 (26.9%) | 2/26 (7.7%) | 2/26 (7.7%) | 1/26 (3.8%) | 2/26 (7.7%) | 23/26 (88.5%) | 6/265 (23.1%) | 5/26 (19.2%) |
Control | 23/107 (21.5%) | 4/107 (2.4%) | 11/107 (10.3%) | 6/107 (5.6%) | 6/107 (5.6%)4 | 82/107 (76.6%) | 5/107 (4.7%) | 1/107 (0.9%) |
CRS & ROM | 9/38 (23.7%) | 9/386 (23.7%) | 20/386 (52.6%) | 0 | 0 | 7/38 (18.4%) | 38/38 (100%) | 13/38 (34.2%) |
FA | 5/24 (20.8%) | 2/24 (8.3%) | 2/24 (8.3%) | 2/24 (8.3%) | 3/24 (12.5%) | 22/24 (91.7%) | 1/24 (4.3%) | 1/242 (4.3%) |
Control7 | 8/43 (18.6%) | 6/43 (14.0%) | 2/43 (4.7%) | 2/43 (4.7%) | 0 | 0 | 0 | 0 |
- 1 Abbreviations: AC allergic conjunctivitis, AD atopic dermatitis, AR allergic rhinitis, ASD autism spectrum disorders, CRS chronic rhinosinusitis, FA food allergy, PID primary immunodeficiency, ROM recurrent otitis media.
- 2 PID; ASD test/control groups: all diagnosed as specific Ab deficiency against polysaccharide Ags (SPAD), CRS/ROM group: 9 SPAD, 2 XLA, 1 dysmotile cilia syndrome, FA group: 1 patient was diagnosed as IgA deficiency. All the ASD test group children diagnosed with SPAD suffered from CRS/ROM.
- 3 Seizure disorders were reported in 4/26 (15.4%) ASD-Test and 2/107 (1.9%) ASD-control groups, respectively.
- 4 IgE mediated food allergy in ASD control group; all allergy to peanuts/tree nuts.
- 5 Frequency of CRS/ROM and PID were higher in the ASD test group (p = 0.0334 and p = 5.762e-07, respectively, by χ2 test).
- 6 Frequency of atopic asthma and non-atopic asthma is higher in CRS/ROM children than other study groups (p = 0.00722 and p = 8.885e-10, respectively, by χ2 test).
- 7 Control children diagnosed with asthma had either mild intermittent or mild to moderate persistent asthma and seldom required oral steroid burst.
