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Table 2 Prevalence of atopy, food allergy, CRS/ROM and primary immunodeficiency in study subjects

From: Impact of innate immunity in a subset of children with autism spectrum disorders: a case control study

Group AR+AC Asthma AD FA CRS & ROM PID2
   Atopy+ Atopy -   IgE non-IgE   
ASD1         
Test3 7/26
(26.9%)
2/26
(7.7%)
2/26
(7.7%)
1/26
(3.8%)
2/26
(7.7%)
23/26
(88.5%)
6/265
(23.1%)
5/26
(19.2%)
Control 23/107
(21.5%)
4/107
(2.4%)
11/107
(10.3%)
6/107
(5.6%)
6/107
(5.6%)4
82/107
(76.6%)
5/107
(4.7%)
1/107
(0.9%)
CRS & ROM 9/38
(23.7%)
9/386
(23.7%)
20/386
(52.6%)
0 0 7/38
(18.4%)
38/38
(100%)
13/38
(34.2%)
FA 5/24
(20.8%)
2/24
(8.3%)
2/24
(8.3%)
2/24
(8.3%)
3/24
(12.5%)
22/24
(91.7%)
1/24
(4.3%)
1/242
(4.3%)
Control7 8/43
(18.6%)
6/43
(14.0%)
2/43
(4.7%)
2/43
(4.7%)
0 0 0 0
  1. 1 Abbreviations: AC allergic conjunctivitis, AD atopic dermatitis, AR allergic rhinitis, ASD autism spectrum disorders, CRS chronic rhinosinusitis, FA food allergy, PID primary immunodeficiency, ROM recurrent otitis media.
  2. 2 PID; ASD test/control groups: all diagnosed as specific Ab deficiency against polysaccharide Ags (SPAD), CRS/ROM group: 9 SPAD, 2 XLA, 1 dysmotile cilia syndrome, FA group: 1 patient was diagnosed as IgA deficiency. All the ASD test group children diagnosed with SPAD suffered from CRS/ROM.
  3. 3 Seizure disorders were reported in 4/26 (15.4%) ASD-Test and 2/107 (1.9%) ASD-control groups, respectively.
  4. 4 IgE mediated food allergy in ASD control group; all allergy to peanuts/tree nuts.
  5. 5 Frequency of CRS/ROM and PID were higher in the ASD test group (p = 0.0334 and p = 5.762e-07, respectively, by χ2 test).
  6. 6 Frequency of atopic asthma and non-atopic asthma is higher in CRS/ROM children than other study groups (p = 0.00722 and p = 8.885e-10, respectively, by χ2 test).
  7. 7 Control children diagnosed with asthma had either mild intermittent or mild to moderate persistent asthma and seldom required oral steroid burst.