Table 1 Substantia nigra tissue ELISA. Levels of cytokines/chemokines in the substantia nigra 12 days following an intra-nigra injection of LPS/saline or intra-striatal injection of 6-OHDA/saline.
Cytokine or Chemokine | Substantia nigra protein levels (pg/mg) ± SEM | |||
|---|---|---|---|---|
Substantia nigra | Striatum | |||
SAL | LPS | SAL | 6OHDA | |
IL-1β | 7.17 ± 0.64 | 13.54 ± 0.69** | 7.58 ± 0.64 | 6.92 ± 0.71 |
MCP-1 | 5.12 ± 0.71 | 8.14 ± 0.64* | 3.96 ± 0.25 | 5.07 ± 0.42 |
IL-4 | 0.46 ± 0.07 | 0.26 ± 0.01* | 0.63 ± 0.16 | 0.45 ± 0.03 |
IFN-γ | 9.88 ± 1.48 | 8.02 ± 0.49 | 13.00 ± 1.32 | 10.11 ± 1.13 |
IL-10 | 1.73 ± 0.05 | 1.46 ± 0.17 | 1.74 ± 0.13 | 1.61 ± 0.10 |
IL-2 | 20.58 ± 0.98 | 23.17 ± 4.33 | 24.05 ± 1.71 | 22.84 ± 1.29 |
TNF-α | 5.66 ± 0.20 | 6.82 ± 0.18 | 6.92 ± 0.80 | 6.47 ± 0.43 |
Fractalkine | 20.67 ± 2.07 | 18.40 ± 1.20 | 19.91 ± 1.04 | 20.73 ± 0.55 |
IL-6 | 5.95 ± 0.60 | 5.32 ± 0.37 | 5.65 ± 0.49 | 5.97 ± 0.40 |