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Table 2 Striatum tissue ELISA. Levels of cytokines/chemokines in the striatum12 days following an intra-nigral injection of LPS/saline or intra-striatal injection of 6-OHDA/saline.

From: Neuroinflammation mediated by IL-1β increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease

Cytokine or Chemokine

Striatum protein levels (pg/mg) ± SEM

 

Substantia nigra

Striatum

 

SAL

LPS

SAL

6OHDA

IL-1β

2.29 ± 0.45

2.41 ± 0.26

3.03 ± 0.48

2.96 ± 0.35

MCP-1

0.76 ± 0.06

0.79 ± 0.06

6.20 ± 1.24

4.36 ± 1.76

IL-4

0.20 ± 0.03

0.25 ± 0.05

0.13 ± 0.02

0.17 ± 0.04

IFN-γ

3.58 ± 0.46

3.76 ± 0.39

3.95 ± 0.41

3.89 ± 0.26

IL-10

0.61 ± 0.07

0.57 ± 0.04

0.69 ± 0.04

0.68 ± 0.05

IL-2

10.02 ± 0.70

10.01 ± 0.79

10.08 ± 0.36

10.99 ± 0.92

TNF-α

2.50 ± 0.20

2.44 ± 0.18

2.43 ± 0.27

2.56 ± 0.14

Fractalkine

14.33 ± 0.80

13.97 ± 0.21

15.54 ± 0.71

16.59 ± 0.86

IL-6

2.81 ± 0.27

3.19 ± 0.24

3.14 ± 0.46

2.78 ± 0.29

  1. SAL, saline; LPS, lipopolysaccharide