Table 3 Cytokine and chemokine protein levels (pg/mg) ± SEM in substantia nigra of animals treated with IL-1ra or vehicle. All animals received an intra-nigra injection of LPS 9 days prior to drug treatment. IL-1ra treatment lasted for 3 days.

IL-1β

9.32 ± 1.38

9.61 ± 2.48

MCP-1

12.48 ± 2.58

10.56 ± 1.71

IFN-γ

2.42 ± 0.38

1.32 ± 0.23*

IL-10

0.22 ± 0.03

0.15 ± 0.02

IL-1α

1.27 ± 0.04

1.03 ± 0.17

TNF-α

2.35 ± 0.29

1.16 ± 0.22*

Fractalkine

14.64 ± 1.37

15.21 ± 1.45

IL-6

13.18 ± 2.71

9.13 ± 1.25