Plaque complement activation and cognitive loss in Alzheimer's disease

Table 2 Subject cognitive measures

Group	Last MMSE	Global cognition	Episodic memory	Semantic memory	Working memory	Perceptual speed	Visuospatial ability
AN	27.76 ± 0.47	0.12 ± 0.05	0.28 ± 0.08	0.21 ± 0.12	-0.07 ± 0.08	-0.10 ± 0.13	0.03 ± 0.12
MCI	27.42 ± 0.81	-0.37 ± 0.16	-0.39 ± 0.21	-0.37 ± 0.21	0.01 ± 0.18	-0.72 ± 0.26	-0.56 ± 0.22
AD	16.89^a ± 1.99	-1.71^a ± 0.21	-2.19^a ± 0.27	-1.44^a ± 0.24	-1.24^a ± 0.22	-1.73^a ± 0.22	-1.16^b ± 0.20

AD differed from the other groups with regard to last MMSE score, global cognition, episodic memory, semantic memory, working memory, and perceptual speed. Visuospatial ability was different only between AD and AN subjects. Data are expressed as means ± SEM. Abbreviations: AD, Alzheimer's disease; AN, aged normal subjects; MCI, subjects with mild cognitive impairment; MMSE, minimental state examination. (^ap < 0.05 vs. AN and MCI; ^bp < 0.05 vs. AN)

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