Figure 1

Scatter plots of individual behavioral scores. Relationship between lesion severity (percent loss of tyrosine hydroxylase [TH] immunoreactivity in the substantia nigra [SN]) and behavioral scores in PBS-treated (open circles, n = 6) and MSC-transplanted (closed circles, n = 11) animals. The behavioral performance of nonlesioned naive rats is indicated by the shaded region (mean ± SEM). A linear regression analysis was performed on the scatter plots (solid line); correlation coefficients are listed for each analysis. Amphetamine- and apomorphine-induced rotation was not linearly related to lesion severity, therefore no linear regression is shown for these plots. Two of the MSC-transplanted animals (indicated by asterisks) with nearly complete nigral lesions performed more similarly to animals with partial lesions in some of the behavioral tests.