Figure 5

MHC I (OX18) immunoreactivity in striatum. (A) MHC class I staining in PBS controls was closely confined to the injection tract. (B-C) In animals receiving Wistar (WIS) MSC or ACI MSC (same rats shown in Fig. 2), a large area of the host striatum was infiltrated with MHC class I immunoreactive cells, although MHC expression was most intense surrounding and within the injection tract. (D) MHC class I staining occupied 15–20% of the striatum in MSC-transplanted animals, compared to less than 5% in PBS controls (graph shows means ± SEM; *p < 0.05). Scale bars = 80 μm.