Figure 6

MHC II (OX6) immunoreactivity in striatum. (A) MHC class II staining in PBS controls was closely confined to the injection tract. (B-C) In animals receiving Wistar (WIS) MSC or ACI MSC (same rats shown in Fig. 2) MHC class II immunoreactivity was widespread in the striatum, but it was most intense surrounding and within the injection tract. (D) MHC class II staining was present in 20–40% of the striatum in MSC-transplanted animals, compared to less than 10% in PBS controls (graph shows means ± SEM; *p < 0.05). Scale bars = 80 μm.