Table 1 Oligo-DNA microarray analysis of cytokine genes that exhibited a ± 2.0 fold change in expression level between the left (uninjured) and right (injured) brain hemispheres (4 h post-injury).
Gene Name | Gene Bank # | PBBI Regulation (fold change) | NNZ-2566/PBBI Regulation (fold change) |
|---|---|---|---|
Chemokine (C-C motif) ligand 2 | NM_031530 | ↑ 21.2 | ↑ 4.0 |
Chemokine (C-X-C motif) ligand 2 | NM_053647 | ↑ 20.0 | ↑ 4.6 |
Interleukin 6 | NM_012589 | ↑ 12.4 | ↑ 5.1 |
Interleukin 1 beta | NM_031512 | ↑ 11.9 | ↑ 2.8 |
Interleukin 1 alpha | NM_017019 | ↑ 7.0 | ↑ 32 |
Interleukin 1 receptor, type II | NM_053953 | ↑ 6.8 | ↑ < 2 (1.1) |
Chemokine (C-X-C motif) ligand 10 | NM_139089 | ↑ 3.2 | ↑ 2.3 |
Chemokine (C-C motif) ligand 3 | NM_013025 | ↑ 3.0 | ↑ 2.3 |
Interleukin 4 receptor | NM_133380 | ↑ 2.8 | ↑ < 2 |
Chemokine (C-C motif) ligand 20 | NM_019233 | ↑ 2.7 | ↑ < 2 (1.0) |
Interleukin 6 receptor | NM_017020 | ↑ < 2 (1.1) | ↓ 2.4 |
CREB binding protein | NM_133381 | ↑ < 2 (1.1) | ↓ 2.0 |
Lymphotoxin A | NM_080769 | ↓ 2.2 | ↓ < 2 (1.9) |
Fibroblast growth factor receptor 3 | NM_053429 | ↓ < 2 (1.5) | ↓ 2.1 |
Transforming growth factor alpha | NM_012671 | ↓ < 2 (1.1) | ↓ 2.2 |