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Table 1 Oligo-DNA microarray analysis of cytokine genes that exhibited a ± 2.0 fold change in expression level between the left (uninjured) and right (injured) brain hemispheres (4 h post-injury).

From: NNZ-2566 treatment inhibits neuroinflammation and pro-inflammatory cytokine expression induced by experimental penetrating ballistic-like brain injury in rats

Gene Name Gene Bank # PBBI
Regulation (fold change)
NNZ-2566/PBBI Regulation (fold change)
Chemokine (C-C motif) ligand 2 NM_031530 ↑ 21.2 ↑ 4.0
Chemokine (C-X-C motif) ligand 2 NM_053647 ↑ 20.0 ↑ 4.6
Interleukin 6 NM_012589 ↑ 12.4 ↑ 5.1
Interleukin 1 beta NM_031512 ↑ 11.9 ↑ 2.8
Interleukin 1 alpha NM_017019 ↑ 7.0 ↑ 32
Interleukin 1 receptor, type II NM_053953 ↑ 6.8 ↑ < 2 (1.1)
Chemokine (C-X-C motif) ligand 10 NM_139089 ↑ 3.2 ↑ 2.3
Chemokine (C-C motif) ligand 3 NM_013025 ↑ 3.0 ↑ 2.3
Interleukin 4 receptor NM_133380 ↑ 2.8 ↑ < 2
Chemokine (C-C motif) ligand 20 NM_019233 ↑ 2.7 ↑ < 2 (1.0)
Interleukin 6 receptor NM_017020 ↑ < 2 (1.1) ↓ 2.4
CREB binding protein NM_133381 ↑ < 2 (1.1) ↓ 2.0
Lymphotoxin A NM_080769 ↓ 2.2 ↓ < 2 (1.9)
Fibroblast growth factor receptor 3 NM_053429 ↓ < 2 (1.5) ↓ 2.1
Transforming growth factor alpha NM_012671 ↓ < 2 (1.1) ↓ 2.2
  1. The results of the microarray were quantified using GEArray Expression Analysis Suite. Data are pooled from 6 rats per group and expressed as folds over uninjured brain hemisphere.