Early VSOP enhancement. In regions of blood brain barrier breakdown visualized by Gd-DTPA (A1, B1, C1), parenchymal VSOP leakage was detectable within the initial 6 h post application (A2, B2). Lesions became clearly distinguishable from the vasculature only after the blood pool contrast resolved. In C2, 4 h post application, intravascular VSOP is still visible. Eight hours after application, neuroinflammatory foci remain hypointense, where as intravascular signal decrease vanished (C3). Ellipses highlight contrast enhancing lesions.