Beyond blood brain barrier breakdown – in vivodetection of occult neuroinflammatory foci by magnetic nanoparticles in high field MRI

Table 1 Distribution and number of contrast enhancing lesions (CEL).

Brain region	Exclusively VSOP enhancement	Gd-DTPA and VSOP enhancement	Total number of CEL
Brain stem	+++	+++++++++	12
Periventricular	++	++++++++++	12
Midbrain		+++++++++	9
Cerebellum	++	++++++	8
Olfactory bulb	+++	+++++	8
Cortex	+++	+++	6
	13	42	55

Data are given from 14 mice after Gd-DTPA and VSOP administration, respectively. Three mice received VSOP only and are not included in the table. Each + refers to an individual animal.

ISSN: 1742-2094