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Table 2 Studied SNPs

From: Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease

Gene

SNP

 

Minor allele frequency in controls

LD in controls

   

North

Europe

North

Spain

Difference

(p)

With

D'

r2

IL6

rs1800795

-174G/C

41.1% (C)

32.8% (C)

< 0.0001

rs2069837

0.998

0.055

 

rs2069837

Intron 2 A/G

7.3% (G)

9.3% (G)

0.03

   

IL10

rs1800896

-1082G/A

50.7% (G)

43.1% (G)

< 0.0001

rs1800871

0.999

0.296

      

rs3024505

0.988

0.191

 

rs1800871

-819C/T

22.5% (T)

26.7% (T)

0.002

rs3024505

0.999

0.058

 

rs3024505

3' C/T

16.6% (T)

14.2% (T)

0.06

   
  1. SNP = single nucleotide polymorphism; LD = linkage disequilibrium; D' = ratio of observed LD to maximum possible LD; r = correlation coefficient; IL6 and IL10 = the genes for interleukin-6 and interleukin-10, respectively.