Adjusted† synergy factor (95% CI, p) in the risk of AD
1.7 (1.05–2.6, 0.03)
2.0 (0.9–4.4, 0.09)
1.6 (1.1–2.4, 0.01)
IL6 and IL10 = the genes for interleukin-6 and interleukin-10, respectively; G+ and T+ group the genotypes, GA+GG and CT+TT, respectively; CI = confidence interval; AD = Alzheimer's disease; APOEε4 = apolipoprotein E ε4.
*To detect a synergy factor of 1.6 (as in the overall dataset) at 0.05.
†All analyses controlled for centre, age, gender and APOEε4 genotype.
‡North Europe = Rotterdam, Bonn, OPTIMA, Nottingham and Bristol; North Spain = Santander and Oviedo.