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Table 5 Interaction between IL6 rs2069837 AA vs G+ and IL10 rs1800871 CC vs T+, by region

From: Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease

Region

Power*

Adjusted† synergy factor (95% CI, p) in the risk of AD

North Europe‡

64%

1.7 (1.05–2.6, 0.03)

North Spain‡

37%

2.0 (0.9–4.4, 0.09)

All

76%

1.6 (1.1–2.4, 0.01)

  1. IL6 and IL10 = the genes for interleukin-6 and interleukin-10, respectively; G+ and T+ group the genotypes, GA+GG and CT+TT, respectively; CI = confidence interval; AD = Alzheimer's disease; APOEε4 = apolipoprotein E ε4.
  2. *To detect a synergy factor of 1.6 (as in the overall dataset) at 0.05.
  3. †All analyses controlled for centre, age, gender and APOEε4 genotype.
  4. ‡North Europe = Rotterdam, Bonn, OPTIMA, Nottingham and Bristol; North Spain = Santander and Oviedo.
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Journal of Neuroinflammation

ISSN: 1742-2094