Figure 3
Time course of changes in intolerable heat pain evoking temperature after intradermal injection of magnesium solution. Fifteen volunteers were intradermally injected with 0.5 M MgSO4 (black square), 0.05 M MgSO4 (white square), 0.05 M MgCl2 (black triangle), or saline (white circle). Each volunteer was injected with three kinds of magnesium solution at intervals of at least one week. Intolerant heat pain temperature was decreased at least 10 min following local administration of Mg2+. *p < 0.05 vs. control; **p < 0.01 vs. control, ***p < 0.001 vs. control. As values were similar among these three saline injections, we have put the representative data herein.