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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Cerebellar Purkinje cells incorporate immunoglobulins and immunotoxins in vitro: implications for human neurological disease and immunotherapeutics

Figure 1

Neurons incorporating IgG contain calbindin, identifying them as Purkinje cells. Cultures were incubated with normal human IgG for intervals of up to 96 hours, fixed, permeabilized, and immunolabeled for calbindin (Panel A: blue) as a marker for Purkinje cells and IgG (Panel B: red). Panel C shows the merged image for both calbindin and IgG (magenta). Uptake of IgG is confined to cells expressing calbindin. (Objective magnification 40×)

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