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Figure 5 | Journal of Neuroinflammation

Figure 5

From: Administration of S-nitrosoglutathione after traumatic brain injury protects the neurovascular unit and reduces secondary injury in a rat model of controlled cortical impact

Figure 5

Effect of GSNO on neuronal apoptotic cell death (TUNEL assay) at 72 h after CCI. Traumatic penumbral region in CCI+VEH brain had a significantly higher number of TUNEL positive cells compared to CCI+GSNO treated brain. Sham brain had no TUNEL positive cells (A). TUNEL positive cells were found to colocalize with neuronal marker NSE (B). Number of TUNEL positive cells (C) and number of stained positive cells (D) were counted in three different fields and averaged. Data are presented as mean ± SD TUNEL staining was carried out as described in Methods. Photomicrographs are the representative of n = 3 in each group. **p < 0.01 vs. Sham and CCI+GSNO.

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Journal of Neuroinflammation

ISSN: 1742-2094