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Figure 3 | Journal of Neuroinflammation

Figure 3

From: The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres

Figure 3

CD88 in the stratum lucidum co-localised with presynaptic proteins. (A-F) Immunolabelling for CD88 (red) in the stratum lucidum displayed almost complete co-localization with the immunolabelling for the presynaptic protein synaptophysin (SNP)(green). There was a highly degree of co-localization of immunolabelling for CD88 and synaptophysin (yellow/orange) within the stratum lucidum of the hippocampus. (G-L) Immunolabelling for CD88 (red) in the stratum lucidum of the hippocampus co-localized with immunolabelling for the presynaptic protein synapsin-1 (SYN) (green). There was a highly degree of co-localization of immunolabelling for CD88 and SYN (yellow/orange) within the stratum lucidum of the hippocampus. (J-O) Immunolabelling for CD88 (red) did not co-localize with immunolabelling for neurofilament (NF, a marker of preterminal portions of the axon) (green). Immunolabelling for NF within the stratum lucidum did not co-localize with immunolabelling for CD88. NF, neurofilament; SNP, synaptophysin; SYN, synapsin. Scale bars = A-C, 200 μm; D-F, 20 μm; G-I, 200 μm; J-L, 20 μm; M-O, 200 μm.

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