Table 1 Brain mRNA expression of complement components in APP23 and non-transgenic controls at 24 months
|  | pathway/function | control mice ± SEM | APP23 ± SEM | p (2 tailed t-test) | increase APP23 |
|---|---|---|---|---|---|
C1q | classical pathway | 89'040 ± 4'788 | 189'896 ± 7'721 | 0.000000006 | 2× |
C4 | classical pathway | 10'042 ± 1'104 | 11'016 ± 1'754 | 0.64 | 1× |
factor B | alternative pathway | 647 ± 92 | 1'029 ± 164 | 0.06 | 1.6× |
C3 | all pathways | 3'317 ± 114 | 10'550 ± 1'507 | 0.0007 | 3 |
C5 | terminal sequence | 117 ± 11 | 128 ± 12 | 0.51 | 1× |
C6 | terminal sequence | 13 (below limit of quantification) | 43 (below limit of quantification) | - | - |
C8a | terminal sequence | not detectable | not detectable | - | - |
C8b | terminal sequence | 32 (below limit of quantification) | 46 (below limit of quantification) | - | - |
C9 | terminal sequence | not detectable | not detectable | - | - |
Crry | inhibitor all pathways | 48'546 ± 4'156 | 49'891 ± 3'120 | 0.80 | 1× |
MCP | inhibitor all pathways | 20 (below limit of quantification) | 37 (below limit of quantification) | - | - |
factor H | inhibitor alternative pathway | 14'756 ± 723 | 21'509 ± 913 | 0.00001 | 1.5× |