Figure 5

Cytokine analysis by ELISA. IL-1β (A), IL-8 (B) and MIP-1β (C) are significantly increased in brains of patients with epilepsy (p < 0.05) whereas. IL-6 (D), MCP-1 (E) and IP-10 (F) show sporadic and variable increases in our patients with epilepsy. Note that some of our patients show highly elevated cytokine release comparable to Rasmussen's encephalitis (black circle). IL-6 (G) and MCP-1 (H) are significantly increased in brains from patients with a family history of epilepsy (p < 0.05). Rasmussen's encephalitis patient (black circle) is the only one who shows high IL-6 and MCP-1 levels among the patients without family history of epilepsy.