Table 1 Changes in early gene expression: neurotransmitters, ion channels and exchangers, apoptosis, mitochondria and glutathione metabolism

S50879

acetylcholinesterase T subunit

2.07*

AF050662

activity and neurotransmitter-induced early gene 10

-3.89*

-5.27**

AF050664

activity and neurotransmitter-induced early gene 12

2.79*

AF050661

activity and neurotransmitter-induced early gene 9

-2.91*

-4.64**

-3.71*

X57659

adrenergic receptor, alpha 2 c-4

2.53***

M16406

cholinergic receptor, muscarinic m1

-2.05*

-2.07*

J05231

cholinergic receptor, nicotinic, alpha 5

-2.29***

L08227

cholinergic receptor, nicotinic, alpha 6

-3.26*

L31619

cholinergic receptor, nicotinic, alpha 7

-2.14**

-2.29**

L31622

cholinergic receptor, nicotinic, beta 2

-2.33**

M35077

dopaminergic receptor A1

-12.11***

-14.19***

A17753

dopaminergic receptor D3

-10.31***

-5.21*

-8.28**

L08493

GABA-A receptor, alpha 4

-2.0*

S56679

glutamate receptor, AMPA-selective A

-3.31***

U08255

glutamate receptor, ionotropic, delta 1

2.68****

AF027331

glutamate receptor, ionotropic, kainate 5

2.15*

D13211

glutamate receptor, ionotropic, NMDA 2A

-3.02**

-3.50***

X96790

glutamate receptor, metabotropic 7b.

-9.46****

-3.02**

-3.50***

D16817

glutamate receptor. metabotropic 7

-2.19*

U28504

glutamate transporter, vesicular, family 17

-3.29*

X55246

glycine receptor, alpha 1

-3.05****

D00833

glycine receptor, alpha 1 subunit

-2.21*

-7.08****

X57281

glycine receptor, alpha 2 subunit

-2.36***

L13600

glycine transporter 1

2.86***

2.12***

U66274

neuropeptide Y receptor 5

-18.76**

-8.72*

X56306

preprotachykinin A (substance P precursor)

-7.17**

L46874

proton-driven peptide transporter.

-2.10**

-3.50***

X90561

purinergic receplor P2X, ligand-gated 3

-5.56*

X80477

purinergic receptor P2X, ligand-gated 1

-3.23*

-3.0***

AF020758

purinergic receptor P2X, ligand-gated 2

-3.86*

-3.81*

X95882

purinergic receptor P2X, ligand-gated 7

-2.10*

U56839

purinergic receptor P2Y, G-protein coupled 2

3.51***

2.41***

Y311433

purinergic receptor P2Y, G-protein coupled 4

-2.53*

X66842

serotonergic receptor 2B

-2.09***

U20907

serotonergic receptor 4

-6.05****

ION CHANNELS

M99222

Ca++ channel, A/P type, alpha 1, splice variant

-3.75*

M57682

Ca++ channel, voltage-gated, L type, alpha 1D

-4.62***

-3.39*

-7.36***

D26111

Cl- channel (ClC-K2L and ClC-K2S), splice variant

-3.13*

-2.02*

X62894

Cl- channel, voltage-gated, 1 (skeletal muscle)

-2.80**

-2.59*

X78461

K+ inwardly-rectifying channel, J12 (kir 3.3/IRK3)

2.05*

U69884

K+ channel, small conductance Ca++-activated

-3.17*

-2.55*

L35771

K+ channel, inwardly-rectifying, J5

-3.56***

L77929

K+ channel, inwardly-rectifying, J9

-2.49*

U40603

K+ channel, large conductance Ca++activated M alpha1

-3.50*

-3.61*

AB010963

K+ channel, large conductance Ca++-activated M beta1

-2.20***

D10709

K+ channel, lsk1 (epithelial), E1

2.50***

AF031384

K+ channel, voltage-gated, K3

-2.45*

-2.36**

AF087453

K+ channel, voltage-gated, KQT-like 2

-3.39*

AF087454

K+ channel, voltage-gated, Q3

-2.56*

-2.18*

Y17606

K+ channel, voltage-gated, S1

-4.17**

-3.80*

-4.68*

J04731

K+ channel, voltage-gated, shaker related 2

-7.17*

X16003

K+ channel, voltage-gated, shaker related 2.

-2.44*

U72410

K+ inwardly-rectifying channel, J3 (GIRK1)

2.75***

M22253

Na+ channel, voltage-gated, 1 alpha

-9.23***

-6.92**

M91808

Na+ channel, voltage-gated, 1 beta

-2.46****

AF000368

Na+ channel, voltage-gated, 9 alpha

-3.36*

AA891751

Na+ channel, voltage-gated, 3 alpha (CIN3)

-2.10**

Y00766

Na+ channel, voltage-gated. 3 alpha (CIN3)

-2.76**

ATPase ION EXCHANGERS

M99223

Ca++ ATPase, cardiac, fast twitch 1

-3.80**

-2.82*

-2.70**

AA800212

Ca++ ATPase, cardiac, slow twitch 2

-2.06*

-2.35*

Al172499

Ca++ ATPase, plasma membrane 1

3.0***

X76452

Ca++ ATPase, plasma membrane 4

-2.06***

AA956437

ER ATPase, peroxisome biogenesis factor 1

-2.35*

U94911

H+/K+ ATPase, nongastric, alpha 2a

-2.30***

M90398

H+/K+ ATPase, nongastric, alpha 2a

-2.73*

U15176

Na+/K+ ATPase, alpha 4

-3.15*

-2.86*

APOPTOSIS

H31839

Bcl X

2.35**

AF025671

caspase 2

-2.93****

-2.63***

AF072124

caspase 7

3.71***

3.17**

M33605

cytolysin

-2.06***

-2.22***

Al639313

huntingtin associated protein interactive protein

-2.40***

-2.34*

Al176462

programmed cell death 2

-2.47****

MITOCHONDRIA

AJ007488

16s ribosomal RNA, mitochondrial

-4.1****

-2.81**

X72758

COX VIa2, Complex IV

-3.16*

M20183

COX VIc1, Complex IV

-3.76**

M10140

creatine kinase (muscle)

-2.02*

-2.01*

Al044488

ferredoxin 1

-2.27*

-2.61*

D26393

hexokinase II

2.75*

X87884

mitochondrial capsule selenoprotein.

-2.88*

AA799479

NADH dehydrogenase (ubiquinone), Complex I

-2.43***

AA891651

NADH dehydrogenase (ubiquinone), Complex I

-2.20*

-2.61***

AI75973

NADH dehydrogenase (ubiquinone), Complex I

-2.61*

X59736

sarcomeric mitochondrial creatine kinase.

-5.18*

Y00497

superoxide dismutase 2

3.79***

5.82****

2.00**

X68041

superoxide dismutase 3

-2.96**

X59793

ubiquitous mitochondrial creatine kinase

-2.61**

A04674

uncoupling protein 1, proton carrier

-2.19***

GLUTATHIONE-RELATED

U73174

glutathione reductase

2.07*

2.74**

AI138143

glutathione S-transferase, theta 2

-2.04**

S72506

glutathione S-transferase, Yc2 subunit

-5.0**

-3.01*

AI235747

glutathione-S-transferase, alpha (Ya)

-2.36*

-2.22***

M81855

P-glycoprotein, multi-drug resistance 1

5.45**

5.10***