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Table 2 Changes in early gene expression: gene regulation, signaling, cytoplasmic transport and metabolism

From: Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for molecules associated with metabolism, signaling and regulation in central nervous system mixed glial cell cultures

TRANSCRIPTION FACTORS
U04860 aryl hydrocarbon receptor -2.48**** -2.66**  
X14788 CREB 2.46*   2.02*
Hi1677 eIF5 (elongation initiation factor 5)   2.47**  
Al03194 eIF5 (elongation initiation factor 5)   2,06***  
Al638955 fox-1 homolog 4.83**   4.08****
L13261 hepatic nuclear factor 3 (forkhead homolog 1)   2.09***  
L09647 hepatic nuclear factor 3 beta -2.23** -2.29* -2.35**
AB01774 hepatic nuclear factor 3 gamma    -2.21*
X57133 hepatic nuclear factor 4 alpha -2.61** -4.80**** -3.46****
X57133 hepatic nuclear factor 4 alpha -6.63*** -3.69*** -2.92**
D10554 hepatic nuclear factor 4 alpha    -2.38**
AA891041 junB 4.49***   2.48**
X54686 junB 2.29**** 2.83**** 2.14****
L26267 NFkappa B, p105 subunit 3.49** 3.97***  
L23862 POU domain   -2.47**  
NUCLEAR RECEPTORS
U40064 PPAR delta 2.31** 2.06**  
AB011365 PPAR gamma -5.41**** -4.52**** -2.09*
SIGNALING
L26986 adenylyl cyclase, type 8   -4.11*  
U73503 calmodulin kinase II, gamma E -2.26*   
U09583 fyn-related kinase (src homology)    
AB007688 homer 4.03* 4.03****  
AA900503 jagged 1 2.15* 2.35*  
L38483 jagged 1   2.38***  
U13396 Janus kinase 2 (JAK 2) 5.20*** 4.97***  
U13396 Janus kinase 2 (JAK 2) 2.34***   
AJ000557 Janus kinase 2 (JAK 2)   3.36***  
L14951 lyn protein non-receptor kinase 2.45** 2.00*  
L14782 lyn protein non-receptor kinase 2.17***   
AA946094 lyn protein non-receptor kinase 2.14**   
X96488 MAP kinase 12 -2.07*   
M95437 phosphodiesterase 1B   -2.36**  
AL235758 protein kinase A, 2, regulatory subunit   -2.15*  
M18330 protein kinase C, delta 2.11**   
U69109 protein tyrosine kinase 2B 4.59** 3.17**  
AF063890 protein tyrosine kinase 2B 3.30***   
Al113289 protein tyrosine phosphatase, non-receptor 2.31*** 2.45***  
AF05398 ras GTPase activating protein -2.04**   
U69702 receptor serine threonine kinase -2.50* -2.56*  
U69702 receptor serine threonine kinase   -2.56*  
AF097887 Rho family GTPase   -2.07***  
AA892553 STAT 1 10.30***   
X91810 STAT 3 2.49**** 2.42****  
U24175 STAT 5a 3.13*** 4.41***  
L27112 stress activated protein kinase alpha II    2.85***
CYTOPLASMIC TRANSPORT AND DEGRADATION OF PROTEINS
AF077354 heat shock 70 kDa protein 4   2.24**  
AA799492 proteasome (prosome, macropain) alpha 6 9.69****   
AA891383 proteasome (prosome, macropain) alpha 6 3.29***   
D45249 proteasome activating subunit alpha 2.12***   
D45250 proteasome activating subunit beta 3.68***   
D21799 proteasome subunit RC7-1 2.12***   
D10757 proteasome subunit R-RING 6.76****   
D10757 proteasome subunit R-RING 6.45**   
AJ224441 proteasome subunit R-RING -3.62** -3.78***  
H31236 similar to ubiquitin-conjugating enzyme E2D 2    -2.50*
S73007 synuclein alpha (SYN 1) 2.87**   
S73008 synuclein beta (SYN 2) -3.82** 2.58**  
AA874859 ubiquitin ligase (NEDD 4) -2.25* -3.19***  
L38482 ubiquitin-conjugating enzyme   2.01**  
U56407 ubiquitin-conjugating enzyme E2D 2 -4.18*** -6.38*** -4.76***
AA685152 ubiquitin-like protein (NEDD 6) 2.71*** 2.90***  
LIPID SYNTHESIS
S78687 3-OH-3-methylglutaryl CoA reductase -2.34** -2.34**  
J02749 acetyl CoA acyl transferase   -2.34* -2.29*
J03808 acetyl CoA carboxylase -2.40*   
AB010428 cytosolic acyl CoA thioesterase 1 3.91*   
M95591 farnesyl phosphate farnesyl transferase   -2.11***  
Al004900 fatty acid CoA ligase, long chain 2 2.47****   
AA925424 fatty acid CoA ligase, long chain 4 -4.83*** -4.27****  
M33648 mitochondrial 3-OH-3-methylglutaryl CoA synthase    -2.72**
Y09333 mitochondrial acyl CoA thioesterase 2.68**   
D00512 mitochondrial fatty acid acetyl CoA thiolase -2.39*   
AA800303 phospholipid scramblase 3.16*   
U07683 UDP-galactose ceramide galactosyl transferase -3.14*   
AF047707 UDP-glucose:ceramide glycosyltransferase 2.57*** 2.61***  
LIPID SIGNALING
AB00999 CDP-diacylglycerol synthase 9.91**** 6.45****  
AB00999 CDP-diacylglycerol synthase 2.52***   6.40****
AA818983 diacylglycerol kinase beta -4.21**   
U10303 EDG, endothelial sphingolipid GPCR   -6.17**** -2.65*
AA859981 myo-inositol monophosphatase   -2.01***  
D88666 phosphatidyl serine specific phospholipase A   3.08**  
D00036 phospholipase A2, group 1B   -4.15*  
U03763 phospholipase A2, group 5   -4.17**  
L14322 phospholipase C beta 1 -2.37**   
STEROID AND VITAMIN D RELATED
U89280 17-beta hydroxy sterol reductase -2.81**   -3.53****
X97754 17-beta hydroxy sterol reductase, type 1 -4.53***   
L04619 25-OH vitamin D3 24-hydroxylase (Cyp24a1)   -5.20* -4.42*
M95058 steroid 5-alpha reductase 2 -2.04**   
M13646 testosterone 6-beta hydroxylase   -6.91*** -2.03*
Y07534 vitamin D3 25-hydroxylase (Cyp27a1) 2.49*   
MISCELLANEOUS
X02361 alpha-fetoprotein -2.50* -2.56* -2.49*
AA998229 alpha-fetoprotein    -2.22**
M90065 angiotensin receptor, type 1b    -5.02****
U01908 angiotensin receptor, type 2 -3.82**   
J02720 arginase 1    4.82***
X03369 beta tubulin 2b -4.09* -4.90* -11.96***
U60758 carbonic anhydrase II 2.46*   2.10*
Al043968 caveolin 3   -2.44*  
AA817854 ceruloplasmin   2.56*  
L33869 ceruloplasmin   2.04*  
U49049 chapsyn-110 -4.05* -4.77** -29.4****
U09538 fyn-related kinase (src homology)   -2.49**  
J03624 galanin 5.03** 3.22***  
S57565 histamine H2 receptor -2.62**   -2.17**
M11566 kallikrein S3 -2.34** -2.48**  
M27217 kallikrein-related (rGK-8)   -2.88**  
AB005900 low density lipoprotein receptor 1 4.06** 2.18** 5.84**
AI07531 low density lipoprotein receptor 1 3.19****   5.40***
AI030685 nestin -2.77*   
U03699 nitric oxide synthase 2 (iNOS) 14.69*** 14.61***  
AA892953 similar to carbonic anhydrase   2.19*  
U09361 VIP receptor 2 -3.14*   
  1. Values represent averages of fold changes from three separate experiments for each cytokine mixture compared to control. The accession numbers are from Genbank.
  2. ****p < 0.01; ***p < 0.05; **p < 0.10; *p < 0.20.