Table 2 Changes in early gene expression: gene regulation, signaling, cytoplasmic transport and metabolism

U04860

aryl hydrocarbon receptor

-2.48****

-2.66**

X14788

CREB

2.46*

2.02*

Hi1677

eIF5 (elongation initiation factor 5)

2.47**

Al03194

eIF5 (elongation initiation factor 5)

2,06***

Al638955

fox-1 homolog

4.83**

4.08****

L13261

hepatic nuclear factor 3 (forkhead homolog 1)

2.09***

L09647

hepatic nuclear factor 3 beta

-2.23**

-2.29*

-2.35**

AB01774

hepatic nuclear factor 3 gamma

-2.21*

X57133

hepatic nuclear factor 4 alpha

-2.61**

-4.80****

-3.46****

X57133

hepatic nuclear factor 4 alpha

-6.63***

-3.69***

-2.92**

D10554

hepatic nuclear factor 4 alpha

-2.38**

AA891041

junB

4.49***

2.48**

X54686

junB

2.29****

2.83****

2.14****

L26267

NFkappa B, p105 subunit

3.49**

3.97***

L23862

POU domain

-2.47**

NUCLEAR RECEPTORS

U40064

PPAR delta

2.31**

2.06**

AB011365

PPAR gamma

-5.41****

-4.52****

-2.09*

SIGNALING

L26986

adenylyl cyclase, type 8

-4.11*

U73503

calmodulin kinase II, gamma E

-2.26*

U09583

fyn-related kinase (src homology)

AB007688

homer

4.03*

4.03****

AA900503

jagged 1

2.15*

2.35*

L38483

jagged 1

2.38***

U13396

Janus kinase 2 (JAK 2)

5.20***

4.97***

U13396

Janus kinase 2 (JAK 2)

2.34***

AJ000557

Janus kinase 2 (JAK 2)

3.36***

L14951

lyn protein non-receptor kinase

2.45**

2.00*

L14782

lyn protein non-receptor kinase

2.17***

AA946094

lyn protein non-receptor kinase

2.14**

X96488

MAP kinase 12

-2.07*

M95437

phosphodiesterase 1B

-2.36**

AL235758

protein kinase A, 2, regulatory subunit

-2.15*

M18330

protein kinase C, delta

2.11**

U69109

protein tyrosine kinase 2B

4.59**

3.17**

AF063890

protein tyrosine kinase 2B

3.30***

Al113289

protein tyrosine phosphatase, non-receptor

2.31***

2.45***

AF05398

ras GTPase activating protein

-2.04**

U69702

receptor serine threonine kinase

-2.50*

-2.56*

U69702

receptor serine threonine kinase

-2.56*

AF097887

Rho family GTPase

-2.07***

AA892553

STAT 1

10.30***

X91810

STAT 3

2.49****

2.42****

U24175

STAT 5a

3.13***

4.41***

L27112

stress activated protein kinase alpha II

2.85***

CYTOPLASMIC TRANSPORT AND DEGRADATION OF PROTEINS

AF077354

heat shock 70 kDa protein 4

2.24**

AA799492

proteasome (prosome, macropain) alpha 6

9.69****

AA891383

proteasome (prosome, macropain) alpha 6

3.29***

D45249

proteasome activating subunit alpha

2.12***

D45250

proteasome activating subunit beta

3.68***

D21799

proteasome subunit RC7-1

2.12***

D10757

proteasome subunit R-RING

6.76****

D10757

proteasome subunit R-RING

6.45**

AJ224441

proteasome subunit R-RING

-3.62**

-3.78***

H31236

similar to ubiquitin-conjugating enzyme E2D 2

-2.50*

S73007

synuclein alpha (SYN 1)

2.87**

S73008

synuclein beta (SYN 2)

-3.82**

2.58**

AA874859

ubiquitin ligase (NEDD 4)

-2.25*

-3.19***

L38482

ubiquitin-conjugating enzyme

2.01**

U56407

ubiquitin-conjugating enzyme E2D 2

-4.18***

-6.38***

-4.76***

AA685152

ubiquitin-like protein (NEDD 6)

2.71***

2.90***

LIPID SYNTHESIS

S78687

3-OH-3-methylglutaryl CoA reductase

-2.34**

-2.34**

J02749

acetyl CoA acyl transferase

-2.34*

-2.29*

J03808

acetyl CoA carboxylase

-2.40*

AB010428

cytosolic acyl CoA thioesterase 1

3.91*

M95591

farnesyl phosphate farnesyl transferase

-2.11***

Al004900

fatty acid CoA ligase, long chain 2

2.47****

AA925424

fatty acid CoA ligase, long chain 4

-4.83***

-4.27****

M33648

mitochondrial 3-OH-3-methylglutaryl CoA synthase

-2.72**

Y09333

mitochondrial acyl CoA thioesterase

2.68**

D00512

mitochondrial fatty acid acetyl CoA thiolase

-2.39*

AA800303

phospholipid scramblase

3.16*

U07683

UDP-galactose ceramide galactosyl transferase

-3.14*

AF047707

UDP-glucose:ceramide glycosyltransferase

2.57***

2.61***

LIPID SIGNALING

AB00999

CDP-diacylglycerol synthase

9.91****

6.45****

AB00999

CDP-diacylglycerol synthase

2.52***

6.40****

AA818983

diacylglycerol kinase beta

-4.21**

U10303

EDG, endothelial sphingolipid GPCR

-6.17****

-2.65*

AA859981

myo-inositol monophosphatase

-2.01***

D88666

phosphatidyl serine specific phospholipase A

3.08**

D00036

phospholipase A2, group 1B

-4.15*

U03763

phospholipase A2, group 5

-4.17**

L14322

phospholipase C beta 1

-2.37**

STEROID AND VITAMIN D RELATED

U89280

17-beta hydroxy sterol reductase

-2.81**

-3.53****

X97754

17-beta hydroxy sterol reductase, type 1

-4.53***

L04619

25-OH vitamin D3 24-hydroxylase (Cyp24a1)

-5.20*

-4.42*

M95058

steroid 5-alpha reductase 2

-2.04**

M13646

testosterone 6-beta hydroxylase

-6.91***

-2.03*

Y07534

vitamin D3 25-hydroxylase (Cyp27a1)

2.49*

MISCELLANEOUS

X02361

alpha-fetoprotein

-2.50*

-2.56*

-2.49*

AA998229

alpha-fetoprotein

-2.22**

M90065

angiotensin receptor, type 1b

-5.02****

U01908

angiotensin receptor, type 2

-3.82**

J02720

arginase 1

4.82***

X03369

beta tubulin 2b

-4.09*

-4.90*

-11.96***

U60758

carbonic anhydrase II

2.46*

2.10*

Al043968

caveolin 3

-2.44*

AA817854

ceruloplasmin

2.56*

L33869

ceruloplasmin

2.04*

U49049

chapsyn-110

-4.05*

-4.77**

-29.4****

U09538

fyn-related kinase (src homology)

-2.49**

J03624

galanin

5.03**

3.22***

S57565

histamine H2 receptor

-2.62**

-2.17**

M11566

kallikrein S3

-2.34**

-2.48**

M27217

kallikrein-related (rGK-8)

-2.88**

AB005900

low density lipoprotein receptor 1

4.06**

2.18**

5.84**

AI07531

low density lipoprotein receptor 1

3.19****

5.40***

AI030685

nestin

-2.77*

U03699

nitric oxide synthase 2 (iNOS)

14.69***

14.61***

AA892953

similar to carbonic anhydrase

2.19*

U09361

VIP receptor 2

-3.14*