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Table 4 Summary of most upregulated and downregulated gene expression

From: Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for molecules associated with metabolism, signaling and regulation in central nervous system mixed glial cell cultures

MOST UPREGULATED

MOST DOWNREGULATED

Th1

Th1

nitric oxide synthase 2 (iNOS)

neuropeptide Y receptor 5

STAT 1

dopaminergic receptor A1

CDP-diacylglycerol synthase

dopaminergic receptor D3

proteasome (prosome, macropain) alpha 6

glutamate receptor, metabotropic 7b.

proteasome subunit R-RING

Na+ channel, voltage-gated, 1 alpha

P-glycoprotein, multi-drug resistance 1

K+ channel, voltage-gated, shaker related 2

Janus kinase 2 (JAK 2)

hepatic nuclear factor 4 alpha

fox-1 homolog

PPAR gamma

protein tyrosine kinase 2B

fatty acid CoA ligase, long chain 4

caspase 7

17-beta hydroxy sterol reductase, type 1

cytosolic acyl CoA thioesterase 1

diacyl glycerol kinase beta

superoxide dismutase 2

ubiquitin-conjugating enzyme E2D 2

M/M

M/M

nitric oxide synthase 2 (iNOS)

neuropeptide Y receptor 5

CDP-diacylglycerol synthase

glycine receptor, alpha 1 subunit

superoxide dismutase 2

Na+ channel, voltage-gated, 1 alpha

STAT 5a

testosterone 6-beta hydroxylase

P glycoprotein (multi-drug resistance)

ubiquitin-conjugating enzyme E2D 2

Janus kinase 2 (JAK 2)

EDG, endothelial sphingolipid GPCR

homer

dopaminergic receptor D3

NF kappa B, p105 subunit

glutathione S-transferase, Yc2 subunit

purinergic P2Y receptor 2

beta tubulin 2b

caspase 7

hepatic nuclear factor alpha

protein tyrosine kinase 2b

chapsyn-110

Ca++ ATPase, plasma membrane 1

PPAR gamma

Th2

Th2

CDP-diacylglycerol synthase

chapsyn-110

low density lipoprotein receptor 1

dopaminergic receptor A1

arginase 1

beta tubulin 2b

fox-1 homolog

dopaminergic receptor D3

stress activated protein kinase alpha II

Ca++ channel, voltage-gated, L type alpha 1D

K+ inwardly-rectifying channel, J3 (GIRK1)

preprotachykinin A (substance P precursor)

jun B

serotonergic receptor 4

purinergic P2Y receptor 2

purinergic receptor P2X, ligand-gated 3

glycine transporter 1

angiotensin receptor, type 1b

carbonic anhydrase II

ubiquitin-conjugating enzyme E2D 2

CREB

K+ channel, voltage-gated S1

superoxide dismutase 2

25-OH vitamin D3 24-hydroxylase