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Table 4 Summary of most upregulated and downregulated gene expression

From: Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for molecules associated with metabolism, signaling and regulation in central nervous system mixed glial cell cultures

MOST UPREGULATED MOST DOWNREGULATED
Th1 Th1
nitric oxide synthase 2 (iNOS) neuropeptide Y receptor 5
STAT 1 dopaminergic receptor A1
CDP-diacylglycerol synthase dopaminergic receptor D3
proteasome (prosome, macropain) alpha 6 glutamate receptor, metabotropic 7b.
proteasome subunit R-RING Na+ channel, voltage-gated, 1 alpha
P-glycoprotein, multi-drug resistance 1 K+ channel, voltage-gated, shaker related 2
Janus kinase 2 (JAK 2) hepatic nuclear factor 4 alpha
fox-1 homolog PPAR gamma
protein tyrosine kinase 2B fatty acid CoA ligase, long chain 4
caspase 7 17-beta hydroxy sterol reductase, type 1
cytosolic acyl CoA thioesterase 1 diacyl glycerol kinase beta
superoxide dismutase 2 ubiquitin-conjugating enzyme E2D 2
M/M M/M
nitric oxide synthase 2 (iNOS) neuropeptide Y receptor 5
CDP-diacylglycerol synthase glycine receptor, alpha 1 subunit
superoxide dismutase 2 Na+ channel, voltage-gated, 1 alpha
STAT 5a testosterone 6-beta hydroxylase
P glycoprotein (multi-drug resistance) ubiquitin-conjugating enzyme E2D 2
Janus kinase 2 (JAK 2) EDG, endothelial sphingolipid GPCR
homer dopaminergic receptor D3
NF kappa B, p105 subunit glutathione S-transferase, Yc2 subunit
purinergic P2Y receptor 2 beta tubulin 2b
caspase 7 hepatic nuclear factor alpha
protein tyrosine kinase 2b chapsyn-110
Ca++ ATPase, plasma membrane 1 PPAR gamma
Th2 Th2
CDP-diacylglycerol synthase chapsyn-110
low density lipoprotein receptor 1 dopaminergic receptor A1
arginase 1 beta tubulin 2b
fox-1 homolog dopaminergic receptor D3
stress activated protein kinase alpha II Ca++ channel, voltage-gated, L type alpha 1D
K+ inwardly-rectifying channel, J3 (GIRK1) preprotachykinin A (substance P precursor)
jun B serotonergic receptor 4
purinergic P2Y receptor 2 purinergic receptor P2X, ligand-gated 3
glycine transporter 1 angiotensin receptor, type 1b
carbonic anhydrase II ubiquitin-conjugating enzyme E2D 2
CREB K+ channel, voltage-gated S1
superoxide dismutase 2 25-OH vitamin D3 24-hydroxylase
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