Role of platelets in neuroinflammation: a wide-angle perspective

Table 2 Main Constituents of Platelet Secretory Granules

Acronyms
5HT	serotonin; 5-hydroxytryptamine	NAP-2	neutrophil activating peptide-2
ADP, ATP	adenosine diphosphate, -triphosphate	PADGEM	GMP-140. Former names for CD62P
CD144	Glut 3	PAI-1	plasminogen activator inhibitor 1
CD36	GP IV	PBP	platelet basic protein
CD62P	P-selectin; see also PADGEM	PDCI	platelet-derived collegenase inhibitor
CTAP-III	connective tissue activating protein III	PDGF	platelet-derived growth factor
EC	endothelial cell	PDGF	platelet-derived growth factor
ECGF	endothelial cell growth factor	PECAM	CD31; platelet-EC adhesion molecule
EGF	epidermic growth factor	PF4	platelet factor 4
Gbp	guanine binding protein	ßTG	beta thromboglobulin
GDP, GTP	guanine diphosphate, -triphosphate	TFPI	tissue factor pathway inhibitor
HMWK	high molecular weight kininogen	TGFß	transforming growth factor ß
HRGP	histidine-rich glycoprotein	TSP	thrombospondin
IGF	insulin-like growth factor	VEGF	vascular endothelial growth factor
LAMP1, 2	lysosomal associated membrane prot	VPF	vascular permeability factor
LIMP, CD63	lysosomal integral membrane protein	vWF	von Willebrand factor
NAP-2	neutrophil activating peptide-2

The standard abbreviations used are spelled out in Table 2. The contents of each are classified in accordance with most of the sources. The main source was Ch. 7 of Gresele et al [11], with some updates from other sources such as [1]. Similar tables appear are found in textbooks of hematology but details may differ. For example, Table twenty four to three of Colman et al [10] lists about twice as many acid hyrdrolases of the lysosomes. No attempt was made to give a complete listing, i.e. many agents cited in text are not listed here. More details can be found in more recent or specialized sources such as [318]. The subcellular localization of some recently identified secreted substances may not yet be known. Many proteins of the platelet plasma membrane are also found on the membranes of granules and in the invaginations of the membrane known as the open canalicular system (OCS).

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