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Table 5 Platelet chemokines and receptors

From: Role of platelets in neuroinflammation: a wide-angle perspective

Platelet Chemokines and Receptors

 

Platelet Chemokine

Common Name

Receptor(s)

Platelet Chemokine Receptors

CXCL1

GRO-α

CXCR2>CXCR1

CCR1

CXCL4

PF4

CXCR3B, GAG

CCR3

CXCL4L1

PF4alt

unknown

CCR4

CXCL5

ENA-78

CXCR2

CXCR4

CXCL7 [a]

NAP-2

CXCR2>CXCR1

CX3CR1

CXCL8

IL-8

CXCR1, CXCR2

 

CXCL12

SDF-1α

CXCR4

 

CCL2

MCP-1

CCR2

(Those which are disputed are not shown)

CCL3

MIP-1α

CCR1, 2, 3

 

CCL5

RANTES

CCR1, 3, 4, 5

 

CCL17

TARC

CCR4, CCR8

 
  1. Platelet chemokines and their common names are listed at left, then their receptors, not all of which are present on platelets. Those which are present on platelets are listed in the right-most column. As noted in text, there is considerable promiscuity of chemokines towards the receptors, some being more specific than others.
  2. Acronyms for common names of chemokines that activate platelets: CCL17 (TARC): thymus and activating-regulating chemokine; CCL22 (MDC): macrophage-derived chemokine; CXCL12 (SDF-1): stromal cell-derived factor 1alpha; CCL18 (PARC): pulmonary and activation regulated chemokine.