Results of behavioral tests in the rats operated on to create unilateral CCI of the sciatic nerve. Progressive development of evoked mechanical allodynia and thermal hyperalgesia was found in the ipsilateral hind paws (A). No significant changes of mechanical allodynia and thermal hyperalgesia were measured in both either the ipsilateral and or contralateral forepaws (B). Data were expressed as mean ± SE of withdrawal thresholds in grams and withdrawal latency in seconds for mechanical allodynia and thermal hyperalgesia, respectively. * indicates statistically significant difference (p < 0.05) when compared with measurement 1 day before operation.